Document Type : Original research articles
Authors
1
Senior Students, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt.
2
Senior Student, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
3
Pharmaceutical Technology Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt. Misr International University, Cairo, Egypt.
4
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
5
Pharmacognosy Department, Faculty of Pharmacy, Misr International University, (MIU), Cairo Egypt.
6
Pharmaceutical Technology Department, Faculty of Pharmacy, Misr International University (MIU),Cairo, Egypt
Abstract
Introduction: Eggplant fruits (Solanum melongena L.) are widely consumed worldwide due to their generous composition of nutraceuticals. They are enriched with different classes of phenolic phytochemicals. Among the polyphenolic constituents, the fruit peels show high content of quercetin-3-rutinoside, chlorogenic acid and delphinidine-3-rutinoside. The plant possesses various biological activities such as antioxidant and antidiabetic activities. It can manage type 2 diabetes by controlling glucose absorption. Aim of study: The objective of the present study was to standardize delphinidine-3-rutinoside, chlorogenic acid, and quercetin-3-rutinoside, present in the eggplant peels extract, then formulate the extract as a lyophilized tablet, in order to evaluate its effect on glucose levels in an attempt for preparation of a bioactive natural antidiabetic dosage form. Materials and Methods: Various extracts of Eggplant peels were prepared using different extraction solvents. Pharmacodynamics studies were carried out on formulated lyophilized tablets containing the most promising extract. Pharmacodynamics study was conducted to assess the effect of the fruit peels extract on the management of blood glucose level in diabetic rats. Results: The results revealed that the Eggplant fruit peels extract in the form of lyophilized tablets could be promising in controlling the high blood glucose level in type 2 diabetic patients, as the freeze-dried tablets of the Eggplant peels extract resulted in lowering the blood glucose level to ~148 mg/dl after 10 days of twice daily administrations to diabetic rats. Conclusion:this report, addresses the important approach of finding and exploiting the significance of using food wastes in drug discovery.
Keywords
)
View on SCiNiTO